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BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI

X-ray diffraction
2.6Å resolution
PDB entry 1cbw coloured by chain, front view.
PDB entry 1cbw coloured by chain, side view.
PDB entry 1cbw coloured by chain, top view.
Source organism: Bos taurus
Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Pancreatic trypsin inhibitor and Chymotrypsin A chain C
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Multimeric state: hetero tetramer
Accessible surface area: 12476.78 Å2
Buried surface area: 8714.47 Å2
Dissociation area: 821.6 Å2
Dissociation energy (ΔGdiss): 5.26 kcal/mol
Dissociation entropy (TΔSdiss): 10.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133406
Assembly 2 (preferred)
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Assembly Name: Pancreatic trypsin inhibitor and Chymotrypsin A chain C
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Multimeric state: hetero tetramer
Accessible surface area: 12477.16 Å2
Buried surface area: 8929.36 Å2
Dissociation area: 686.04 Å2
Dissociation energy (ΔGdiss): 7.87 kcal/mol
Dissociation entropy (TΔSdiss): 7.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133406
Assembly 3
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Assembly Name: Pancreatic trypsin inhibitor and Chymotrypsin A chain C
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Multimeric state: hetero octamer
Accessible surface area: 22681.77 Å2
Buried surface area: 19918.38 Å2
Dissociation area: 1,178.2 Å2
Dissociation energy (ΔGdiss): 6.33 kcal/mol
Dissociation entropy (TΔSdiss): 13.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-133436

Macromolecules

Chymotrypsin A chain A
Chains: A, F
Length: 13 amino acids
Theoretical weight: 1.25 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00766 (Residues: 1-13; Coverage: 5%)
SCOP: Eukaryotic proteases
Chymotrypsin A chain A in PDB entry 1cbw, assembly 2, front view.
Chymotrypsin A chain A in PDB entry 1cbw, assembly 2, side view.
Chymotrypsin A chain A in PDB entry 1cbw, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P00766  
11312345678910111213
 
510CGVPAIQPVLSGL
UniProt
P00766
Chains
Domains
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Chymotrypsin A chain B
Chains: B, G
Length: 131 amino acids
Theoretical weight: 13.93 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00766 (Residues: 16-146; Coverage: 54%)
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Chymotrypsin A chain B in PDB entry 1cbw, assembly 2, front view.
Chymotrypsin A chain B in PDB entry 1cbw, assembly 2, side view.
Chymotrypsin A chain B in PDB entry 1cbw, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P00766  
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Chymotrypsin A chain C
Chains: C, H
Length: 97 amino acids
Theoretical weight: 10.07 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00766 (Residues: 149-245; Coverage: 40%)
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Chymotrypsin A chain C in PDB entry 1cbw, assembly 2, front view.
Chymotrypsin A chain C in PDB entry 1cbw, assembly 2, side view.
Chymotrypsin A chain C in PDB entry 1cbw, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P00766  
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Pancreatic trypsin inhibitor
Chains: D, I
Length: 58 amino acids
Theoretical weight: 6.53 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00974 (Residues: 36-93; Coverage: 73%)
Pfam: Kunitz/Bovine pancreatic trypsin inhibitor domain
InterPro:
CATH: Pancreatic trypsin inhibitor Kunitz domain
SCOP: Small Kunitz-type inhibitors & BPTI-like toxins
Pancreatic trypsin inhibitor in PDB entry 1cbw, assembly 2, front view.
Pancreatic trypsin inhibitor in PDB entry 1cbw, assembly 2, side view.
Pancreatic trypsin inhibitor in PDB entry 1cbw, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P00974  
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