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SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS

X-ray diffraction
2.1Å resolution
PDB entry 1chq coloured by chain, front view.
PDB entry 1chq coloured by chain, side view.
PDB entry 1chq coloured by chain, top view.
Source organism: Vibrio cholerae
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cholera enterotoxin subunit B
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Multimeric state: homo pentamer
Accessible surface area: 20431.56 Å2
Buried surface area: 11906.84 Å2
Dissociation area: 5,953.42 Å2
Dissociation energy (ΔGdiss): 52.7 kcal/mol
Dissociation entropy (TΔSdiss): 47.4 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-134384

Macromolecules

Cholera enterotoxin subunit B
Chains: D, E, F, G, H
Length: 103 amino acids
Theoretical weight: 11.58 KDa
Source organism: Vibrio cholerae
Expression system: Escherichia coli
UniProt:
  • Canonical: P01556 (Residues: 22-124; Coverage: 100%)
Gene names: VC_1456, ctxB, toxB
Pfam: Heat-labile enterotoxin beta chain
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
SCOP: Bacterial AB5 toxins, B-subunits
Cholera enterotoxin subunit B in PDB entry 1chq, assembly 1, front view.
Cholera enterotoxin subunit B in PDB entry 1chq, assembly 1, side view.
Cholera enterotoxin subunit B in PDB entry 1chq, assembly 1, top view.
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