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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG

Source organisms:
Biochemical function: phosphorus-oxygen lyase activity
Biological process: intracellular signal transduction
Cellular component: not assigned

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EC 4.6.1.1: Adenylate cyclase

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Systematic name:
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Alternative Name(s):
  • 3',5'-cyclic AMP synthetase
  • ATP diphosphate-lyase (cyclizing)
  • ATP pyrophosphate-lyase
  • Adenyl cyclase
  • Adenylyl cyclase
  • Adenylylcyclase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00211
Domain description: Adenylate and Guanylate cyclase catalytic domain
Occurring in:
  1. Adenylate cyclase type 5
  2. Adenylate cyclase type 2
The deposited structure of PDB entry 1cjt contains 1 copy of Pfam domain PF00211 (Adenylate and Guanylate cyclase catalytic domain) in Adenylate cyclase type 5. Showing 1 copy in chain A.
The deposited structure of PDB entry 1cjt contains 1 copy of Pfam domain PF00211 (Adenylate and Guanylate cyclase catalytic domain) in Adenylate cyclase type 2. Showing 1 copy in chain B.

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 1cjt contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001019
Domain description: Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR001054
Domain description: Adenylyl cyclase class-3/4/guanylyl cyclase
Occurring in:
  1. Adenylate cyclase type 5
  2. Adenylate cyclase type 2
IPR000367
Domain description: G-protein alpha subunit, group S
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR029787
Domain description: Nucleotide cyclase
Occurring in:
  1. Adenylate cyclase type 5
  2. Adenylate cyclase type 2
IPR011025
Domain description: G protein alpha subunit, helical insertion
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR018297
Domain description: Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Occurring in:
  1. Adenylate cyclase type 5
  2. Adenylate cyclase type 2

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 1cjt contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain C.
3.30.70.1230
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Nucleotide cyclase
Occurring in:
  1. Adenylate cyclase type 5
  2. Adenylate cyclase type 2
The deposited structure of PDB entry 1cjt contains 1 copy of CATH domain 3.30.70.1230 (Alpha-Beta Plaits) in Adenylate cyclase type 5. Showing 1 copy in chain A.
The deposited structure of PDB entry 1cjt contains 1 copy of CATH domain 3.30.70.1230 (Alpha-Beta Plaits) in Adenylate cyclase type 2. Showing 1 copy in chain B.
1.10.400.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: GI Alpha 1, domain 2-like
Homology: GI Alpha 1, domain 2-like
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 1cjt contains 1 copy of CATH domain 1.10.400.10 (GI Alpha 1, domain 2-like) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain C.
SCOP SCOP annotations
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 1cjt contains 1 copy of SCOP domain 52592 (G proteins) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain C.
55074
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: Nucleotide cyclase
Occurring in:
  1. Adenylate cyclase type 5
  2. Adenylate cyclase type 2
The deposited structure of PDB entry 1cjt contains 1 copy of SCOP domain 55074 (Adenylyl and guanylyl cyclase catalytic domain) in Adenylate cyclase type 5. Showing 1 copy in chain A.
The deposited structure of PDB entry 1cjt contains 1 copy of SCOP domain 55074 (Adenylyl and guanylyl cyclase catalytic domain) in Adenylate cyclase type 2. Showing 1 copy in chain B.
47896
Class: All alpha proteins
Fold: Transducin (alpha subunit), insertion domain
Superfamily: Transducin (alpha subunit), insertion domain
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 1cjt contains 1 copy of SCOP domain 47896 (Transducin (alpha subunit), insertion domain) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain C.

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