› › Structure analysis

THE HIGH-RESOLUTION X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN SUBTILISIN CARLSBERG AND EGLIN C, AN ELASTASE INHIBITOR FROM THE LEECH HIRUDO MEDICINALIS. STRUCTURAL ANALYSIS, SUBTILISIN STRUCTURE AND INTERFACE GEOMETRY

X-ray diffraction
1.2Å resolution
PDB entry 1cse coloured by chain, front view.
PDB entry 1cse coloured by chain, side view.
PDB entry 1cse coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Keratinase and Eglin C
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 12486.05 Å2
Buried surface area: 1581.62 Å2
Dissociation area: 743.8 Å2
Dissociation energy (ΔGdiss): 6.71 kcal/mol
Dissociation entropy (TΔSdiss): 10.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-109146

Macromolecules

Keratinase
Chain: E
Length: 274 amino acids
Theoretical weight: 27.31 KDa
Source organism: Bacillus subtilis
Expression system: Not provided
UniProt:
  • Canonical: B0FXJ2 (Residues: 81-354; Coverage: 77%)
Pfam: Subtilase family
InterPro:
CATH: Peptidase S8/S53 domain
SCOP: Subtilases
Keratinase in PDB entry 1cse, assembly 1, front view.
Keratinase in PDB entry 1cse, assembly 1, side view.
Keratinase in PDB entry 1cse, assembly 1, top view.
Molecule details ›

Search similar proteins

Eglin C
Chain: I
Length: 70 amino acids
Theoretical weight: 8.1 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P01051 (Residues: 1-70; Coverage: 100%)
Pfam: Potato inhibitor I family
InterPro:
CATH: Trypsin Inhibitor V, subunit A
SCOP: CI-2 family of serine protease inhibitors
Eglin C in PDB entry 1cse, assembly 1, front view.
Eglin C in PDB entry 1cse, assembly 1, side view.
Eglin C in PDB entry 1cse, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links