EC 1.14.14.18: Heme oxygenase (biliverdin-producing)
Reaction catalysed:
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O
Systematic name:
Protoheme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Alternative Name(s):
- Heme oxidase
- Heme oxidase
- Heme oxygenase
- Heme oxygenase
- Heme oxygenase (decyclizing)
- Heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
- ORP33 proteins
GO terms
Biochemical function:
Biological process:
- negative regulation of vascular associated smooth muscle cell proliferation
- response to 3-methylcholanthrene
- response to arachidonic acid
- positive regulation of epithelial cell apoptotic process
- negative regulation of epithelial cell apoptotic process
- epithelial cell apoptotic process
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- negative regulation of ferroptosis
- liver regeneration
- positive regulation of cell migration involved in sprouting angiogenesis
- cellular response to cisplatin
- cellular response to cadmium ion
- cellular response to arsenic-containing substance
- multicellular organismal-level iron ion homeostasis
- negative regulation of smooth muscle cell proliferation
- positive regulation of smooth muscle cell proliferation
- positive regulation of angiogenesis
- response to estrogen
- negative regulation of neuron apoptotic process
- negative regulation of mast cell degranulation
- response to hydrogen peroxide
- heme metabolic process
- heme catabolic process
- intracellular signal transduction
- response to nicotine
- cellular response to heat
- erythrocyte homeostasis
- negative regulation of mast cell cytokine production
- cellular response to nutrient
- negative regulation of macroautophagy
- positive regulation of macroautophagy
- macroautophagy
- negative regulation of muscle cell apoptotic process
- response to xenobiotic stimulus
- intrinsic apoptotic signaling pathway in response to DNA damage
- negative regulation of cell population proliferation
- regulation of blood pressure
- small GTPase-mediated signal transduction
- response to oxidative stress
- apoptotic process
- intracellular iron ion homeostasis
- heme oxidation
- phospholipid metabolic process
- regulation of transcription by RNA polymerase II
- wound healing involved in inflammatory response
- response to hypoxia
- angiogenesis
Protein family (Pfam)
InterPro annotations
CATH domain
SCOP annotation