› 1dvz

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH O-TRIFLUOROMETHYLPHENYL ANTHRANILIC ACID

Released:
DOI: 10.2210/pdb1dvz/pdb
PDB entry 1dvz coloured by chain, front view.
PDB entry 1dvz coloured by chain, side view.
PDB entry 1dvz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rational design of potent human transthyretin amyloid disease inhibitors.
Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC
Nat Struct Biol 7 312-21 (2000)
PMID: 10742177

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-144; Coverage: 98%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand OFL 1 x OFL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 42.86Å b: 85.84Å c: 65.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.2
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Molecular mechanisms of amyloidosis.
Merlini et al. (2003)
51 more

3 mentions without citation

Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis.
Kirpotina et al. (2020)
2 more