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D-alanyl-D-lacate ligase

Source organism: Enterococcus faecium
Biochemical function: metal ion binding
Biological process: cell wall organization
Cellular component: plasma membrane

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EC 6.1.2.1: D-alanine--(R)-lactate ligase

Reaction catalysed:
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate
Systematic name:
D-alanine:(R)-lactate ligase (ADP-forming)
Alternative Name(s):
  • VanA
  • VanB
  • VanD

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07478
Domain description: D-ala D-ala ligase C-terminus
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of Pfam domain PF07478 (D-ala D-ala ligase C-terminus) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of Pfam domain PF07478 (D-ala D-ala ligase C-terminus) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.

PF01820
Domain description: D-ala D-ala ligase N-terminus
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of Pfam domain PF01820 (D-ala D-ala ligase N-terminus) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of Pfam domain PF01820 (D-ala D-ala ligase N-terminus) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR005905
Domain description: D-alanine--D-alanine ligase
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
IPR000291
Domain description: D-alanine--D-alanine ligase/VANA/B/C, conserved site
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
IPR013815
Domain description: ATP-grasp fold, subdomain 1
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
IPR011095
Domain description: D-alanine--D-alanine ligase, C-terminal
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
IPR011761
Domain description: ATP-grasp fold
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
IPR011127
Domain description: D-alanine--D-alanine ligase, N-terminal domain
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
IPR016185
Domain description: Pre-ATP-grasp domain superfamily
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA

Structure domains

CATH CATH domains
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.
3.30.1490.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: ATP-grasp fold, A domain
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.
3.40.50.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of CATH domain 3.40.50.20 (Rossmann fold) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of CATH domain 3.40.50.20 (Rossmann fold) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.
SCOP SCOP annotations
56060
Class: Alpha and beta proteins (a+b)
Fold: ATP-grasp
Superfamily: Glutathione synthetase ATP-binding domain-like
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of SCOP domain 56060 (ATP-binding domain of peptide synthetases) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of SCOP domain 56060 (ATP-binding domain of peptide synthetases) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.
52452
Class: Alpha and beta proteins (a/b)
Fold: PreATP-grasp domain
Superfamily: PreATP-grasp domain
Occurring in:
  1. Vancomycin/teicoplanin A-type resistance protein VanA
  2. Vancomycin/teicoplanin A-type resistance protein VanA
The deposited structure of PDB entry 1e4e contains 1 copy of SCOP domain 52452 (D-Alanine ligase N-terminal domain) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e4e contains 1 copy of SCOP domain 52452 (D-Alanine ligase N-terminal domain) in Vancomycin/teicoplanin A-type resistance protein VanA. Showing 1 copy in chain B.

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