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D-alanyl-D-lacate ligase

X-ray diffraction
2.5Å resolution
PDB entry 1e4e coloured by chain, front view.
PDB entry 1e4e coloured by chain, side view.
PDB entry 1e4e coloured by chain, top view.
Source organism: Enterococcus faecium
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vancomycin/teicoplanin A-type resistance protein VanA
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Multimeric state: hetero tetramer
Accessible surface area: 48440.22 Å2
Buried surface area: 22435.17 Å2
Dissociation area: 2,105.71 Å2
Dissociation energy (ΔGdiss): 0.57 kcal/mol
Dissociation entropy (TΔSdiss): 14.84 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-150334

Macromolecules

Vancomycin/teicoplanin A-type resistance protein VanA
Chain: A
Length: 343 amino acids
Theoretical weight: 37.58 KDa
Source organism: Enterococcus faecium
Expression system: Escherichia coli
UniProt:
  • Canonical: P25051 (Residues: 1-343; Coverage: 100%)
Gene name: vanA
Pfam:
InterPro:
CATH:
SCOP:
Vancomycin/teicoplanin A-type resistance protein VanA in PDB entry 1e4e, assembly 1, front view.
Vancomycin/teicoplanin A-type resistance protein VanA in PDB entry 1e4e, assembly 1, side view.
Vancomycin/teicoplanin A-type resistance protein VanA in PDB entry 1e4e, assembly 1, top view.
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Vancomycin/teicoplanin A-type resistance protein VanA
Chain: B
Length: 343 amino acids
Theoretical weight: 37.62 KDa
Source organism: Enterococcus faecium
Expression system: Escherichia coli
UniProt:
  • Canonical: P25051 (Residues: 1-343; Coverage: 100%)
Gene name: vanA
Pfam:
InterPro:
CATH:
SCOP:
Vancomycin/teicoplanin A-type resistance protein VanA in PDB entry 1e4e, assembly 1, front view.
Vancomycin/teicoplanin A-type resistance protein VanA in PDB entry 1e4e, assembly 1, side view.
Vancomycin/teicoplanin A-type resistance protein VanA in PDB entry 1e4e, assembly 1, top view.
Molecule details ›

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