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Bovine F1-ATPase inhibited by DCCD (dicyclohexylcarbodiimide)

Source organism: Bos taurus
Biochemical function: proton-transporting ATP synthase activity, rotational mechanism
Biological process: proton motive force-driven ATP synthesis
Cellular component: proton-transporting ATP synthase complex, catalytic core F(1)

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EC 7.1.2.2: H(+)-transporting two-sector ATPase

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Systematic name:
ATP phosphohydrolase (two-sector, H(+)-transporting)
Alternative Name(s):
  • ATP synthase
  • Bacterial Ca(2+)/Mg(2+) ATPase
  • Chloroplast ATPase
  • Coupling factors (F(o), F(1) and CF(1))
  • F(0)F(1)-ATPase
  • F(1)-ATPase
  • F(o)F(1)-ATPase
  • H(+)-transporting ATP synthase
  • H(+)-transporting ATPase
  • Mitochondrial ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e79 contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.

PF02874
Domain description: ATP synthase alpha/beta family, beta-barrel domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e79 contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.

PF22919
Domain description: C-terminal domain of V and A type ATP synthase
Occurring in:
  1. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of Pfam domain PF22919 (C-terminal domain of V and A type ATP synthase) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.

PF00306
Domain description: ATP synthase alpha/beta chain, C terminal domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of Pfam domain PF00306 (ATP synthase alpha/beta chain, C terminal domain) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.

PF04627
Domain description: Mitochondrial ATP synthase epsilon chain
Occurring in:
  1. ATP synthase subunit epsilon, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of Pfam domain PF04627 (Mitochondrial ATP synthase epsilon chain) in ATP synthase subunit epsilon, mitochondrial. Showing 1 copy in chain I.

PF21335
Domain description: Metazoan delta subunit of F1F0-ATP synthase, C-terminal domain
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of Pfam domain PF21335 (Metazoan delta subunit of F1F0-ATP synthase, C-terminal domain) in ATP synthase subunit delta, mitochondrial. Showing 1 copy in chain H.

PF02823
Domain description: ATP synthase, Delta/Epsilon chain, beta-sandwich domain
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of Pfam domain PF02823 (ATP synthase, Delta/Epsilon chain, beta-sandwich domain) in ATP synthase subunit delta, mitochondrial. Showing 1 copy in chain H.

PF00231
Domain description: ATP synthase
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of Pfam domain PF00231 (ATP synthase) in ATP synthase subunit gamma, mitochondrial. Showing 1 copy in chain G.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
IPR005294
Domain description: ATP synthase, F1 complex, alpha subunit
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
IPR000131
Domain description: ATP synthase, F1 complex, gamma subunit
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial
IPR005722
Domain description: ATP synthase, F1 complex, beta subunit
Occurring in:
  1. ATP synthase subunit beta, mitochondrial
IPR000793
Domain description: ATP synthase, alpha subunit, C-terminal
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
IPR020003
Domain description: ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
IPR004100
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
IPR036121
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
IPR001469
Domain description: ATP synthase, F1 complex, delta/epsilon subunit
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
IPR006721
Domain description: ATP synthase, F1 complex, epsilon subunit, mitochondrial
Occurring in:
  1. ATP synthase subunit epsilon, mitochondrial
IPR024034
Domain description: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
Occurring in:
  1. ATP synthase subunit beta, mitochondrial
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP synthase subunit beta, mitochondrial
IPR038376
Domain description: ATP synthase, alpha subunit, C-terminal domain superfamily
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
IPR033732
Domain description: ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
IPR036742
Domain description: ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial
Occurring in:
  1. ATP synthase subunit epsilon, mitochondrial
IPR036771
Domain description: F0F1 ATP synthase delta/epsilon subunit, N-terminal
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
IPR036794
Domain description: ATP synthase delta/epsilon subunit, C-terminal domain superfamily
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
IPR020546
Domain description: ATP synthase, F1 complex, delta/epsilon subunit, N-terminal
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
IPR023632
Domain description: ATP synthase, F1 complex, gamma subunit conserved site
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial
IPR035968
Domain description: ATP synthase, F1 complex, gamma subunit superfamily
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of CATH domain 3.40.50.300 (Rossmann fold) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e79 contains 3 copies of CATH domain 3.40.50.300 (Rossmann fold) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.
1.10.1140.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3
Homology: Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3
Occurring in:
  1. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of CATH domain 1.10.1140.10 (Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.
2.40.10.170
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Thrombin, subunit H
Occurring in:
  1. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of CATH domain 2.40.10.170 (Thrombin, subunit H) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.
1.20.150.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Lysin
Homology: ATP synthase alpha/beta chain, C-terminal domain
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of CATH domain 1.20.150.20 (Lysin) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
2.40.30.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Elongation Factor Tu (Ef-tu); domain 3
Homology: Elongation Factor Tu (Ef-tu); domain 3
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of CATH domain 2.40.30.20 (Elongation Factor Tu (Ef-tu); domain 3) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
1.10.287.80
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: ATP synthase, gamma subunit, helix hairpin domain
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of CATH domain 1.10.287.80 (Helix Hairpins) in ATP synthase subunit gamma, mitochondrial. Showing 1 copy in chain G.
1.10.1620.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Atp Synthase Epsilon Chain; Chain: I;
Homology: ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial
Occurring in:
  1. ATP synthase subunit epsilon, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of CATH domain 1.10.1620.20 (Atp Synthase Epsilon Chain; Chain: I;) in ATP synthase subunit epsilon, mitochondrial. Showing 1 copy in chain I.
1.20.5.440
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: ATP synthase delta/epsilon subunit, C-terminal domain
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of CATH domain 1.20.5.440 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in ATP synthase subunit delta, mitochondrial. Showing 1 copy in chain H.
2.60.15.10
Class: Mainly Beta
Architecture: Sandwich
Topology: ATP Synthase; domain 1
Homology: F0F1 ATP synthase delta/epsilon subunit, N-terminal
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of CATH domain 2.60.15.10 (ATP Synthase; domain 1) in ATP synthase subunit delta, mitochondrial. Showing 1 copy in chain H.
3.40.1380.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Pyruvate Kinase; Chain: A, domain 1
Homology: Pyruvate Kinase; Chain: A, domain 1
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of CATH domain 3.40.1380.10 (Pyruvate Kinase; Chain: A, domain 1) in ATP synthase subunit gamma, mitochondrial. Showing 1 copy in chain G.
SCOP SCOP annotations
47918
Class: All alpha proteins
Fold: Left-handed superhelix
Superfamily: C-terminal domain of alpha and beta subunits of F1 ATP synthase
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of SCOP domain 47918 (C-terminal domain of alpha and beta subunits of F1 ATP synthase) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e79 contains 3 copies of SCOP domain 47918 (C-terminal domain of alpha and beta subunits of F1 ATP synthase) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.
52670
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of SCOP domain 52670 (RecA protein-like (ATPase-domain)) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e79 contains 3 copies of SCOP domain 52670 (RecA protein-like (ATPase-domain)) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.
50616
Class: All beta proteins
Fold: Domain of alpha and beta subunits of F1 ATP synthase-like
Superfamily: N-terminal domain of alpha and beta subunits of F1 ATP synthase
Occurring in:
  1. ATP synthase subunit alpha, mitochondrial
  2. ATP synthase subunit beta, mitochondrial
The deposited structure of PDB entry 1e79 contains 3 copies of SCOP domain 50616 (N-terminal domain of alpha and beta subunits of F1 ATP synthase) in ATP synthase subunit alpha, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 1e79 contains 3 copies of SCOP domain 50616 (N-terminal domain of alpha and beta subunits of F1 ATP synthase) in ATP synthase subunit beta, mitochondrial. Showing 1 copy in chain D.
48691
Class: All alpha proteins
Fold: Non-globular all-alpha subunits of globular proteins
Superfamily: Epsilon subunit of mitochondrial F1F0-ATP synthase
Occurring in:
  1. ATP synthase subunit epsilon, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of SCOP domain 48691 (Epsilon subunit of mitochondrial F1F0-ATP synthase) in ATP synthase subunit epsilon, mitochondrial. Showing 1 copy in chain I.
46605
Class: All alpha proteins
Fold: Long alpha-hairpin
Superfamily: Epsilon subunit of F1F0-ATP synthase C-terminal domain
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of SCOP domain 46605 (Epsilon subunit of F1F0-ATP synthase C-terminal domain) in ATP synthase subunit delta, mitochondrial. Showing 1 copy in chain H.
51345
Class: All beta proteins
Fold: Epsilon subunit of F1F0-ATP synthase N-terminal domain
Superfamily: Epsilon subunit of F1F0-ATP synthase N-terminal domain
Occurring in:
  1. ATP synthase subunit delta, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of SCOP domain 51345 (Epsilon subunit of F1F0-ATP synthase N-terminal domain) in ATP synthase subunit delta, mitochondrial. Showing 1 copy in chain H.
52944
Class: Alpha and beta proteins (a/b)
Fold: Pyruvate kinase C-terminal domain-like
Superfamily: ATP synthase (F1-ATPase), gamma subunit
Occurring in:
  1. ATP synthase subunit gamma, mitochondrial
The deposited structure of PDB entry 1e79 contains 1 copy of SCOP domain 52944 (ATP synthase (F1-ATPase), gamma subunit) in ATP synthase subunit gamma, mitochondrial. Showing 1 copy in chain G.

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