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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2

X-ray diffraction
1.8Å resolution
PDB entry 1eeo coloured by chain, front view.
PDB entry 1eeo coloured by chain, side view.
PDB entry 1eeo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 13936.57 Å2
Buried surface area: 1087.14 Å2
Dissociation area: 451.96 Å2
Dissociation energy (ΔGdiss): 8.64 kcal/mol
Dissociation entropy (TΔSdiss): 7.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148262

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chain: A
Length: 321 amino acids
Theoretical weight: 37.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18031 (Residues: 1-321; Coverage: 74%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1eeo, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1eeo, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1eeo, assembly 1, top view.
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ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE
Chain: B
Length: 11 amino acids
Theoretical weight: 1.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE in PDB entry 1eeo, assembly 1, front view.
ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE in PDB entry 1eeo, assembly 1, side view.
ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE in PDB entry 1eeo, assembly 1, top view.
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