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Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707

X-ray diffraction
2.1Å resolution
PDB entry 1f0s coloured by chain, front view.
PDB entry 1f0s coloured by chain, side view.
PDB entry 1f0s coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor Xa complex
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Multimeric state: hetero dimer
Accessible surface area: 13588.39 Å2
Buried surface area: 2630.87 Å2
Dissociation area: 875.82 Å2
Dissociation energy (ΔGdiss): 4.22 kcal/mol
Dissociation entropy (TΔSdiss): 10.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133209
Complex Portal ID: CPX-6215

Macromolecules

Activated factor Xa heavy chain
Chain: A
Length: 254 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-488; Coverage: 56%)
Gene name: F10
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Activated factor Xa heavy chain in PDB entry 1f0s, assembly 1, front view.
Activated factor Xa heavy chain in PDB entry 1f0s, assembly 1, side view.
Activated factor Xa heavy chain in PDB entry 1f0s, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P00742  
125420406080100120140160180200220240
 
100200
UniProt
P00742
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
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Factor X light chain
Chain: B
Length: 134 amino acids
Theoretical weight: 15.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 46-179; Coverage: 29%)
Gene name: F10
Pfam:
InterPro:
CATH: Laminin
SCOP: EGF-type module
Factor X light chain in PDB entry 1f0s, assembly 1, front view.
Factor X light chain in PDB entry 1f0s, assembly 1, side view.
Factor X light chain in PDB entry 1f0s, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P00742  
1134102030405060708090100110120130
 
50100
UniProt
P00742
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Molecule details ›

Search similar proteins

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