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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH

X-ray diffraction
2.6Å resolution
PDB entry 1f93 coloured by chain, front view.
PDB entry 1f93 coloured by chain, side view.
PDB entry 1f93 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Hepatocyte nuclear factor 1-alpha and Pterin-4-alpha-carbinolamine dehydratase
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Multimeric state: hetero tetramer
Accessible surface area: 12834.78 Å2
Buried surface area: 4951.73 Å2
Dissociation area: 1,084.94 Å2
Dissociation energy (ΔGdiss): 7.77 kcal/mol
Dissociation entropy (TΔSdiss): 10.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149605
Assembly 2 (preferred)
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Assembly Name: Hepatocyte nuclear factor 1-alpha and Pterin-4-alpha-carbinolamine dehydratase
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Multimeric state: hetero tetramer
Accessible surface area: 12242.31 Å2
Buried surface area: 4835.32 Å2
Dissociation area: 1,053.56 Å2
Dissociation energy (ΔGdiss): 6.72 kcal/mol
Dissociation entropy (TΔSdiss): 9.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149605

Macromolecules

Pterin-4-alpha-carbinolamine dehydratase
Chains: A, B, C, D
Length: 104 amino acids
Theoretical weight: 12.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P61459 (Residues: 1-104; Coverage: 100%)
Gene names: Dcoh, Pcbd, Pcbd1
Pfam: Pterin 4 alpha carbinolamine dehydratase
InterPro:
CATH: Transcriptional coactivator/pterin dehydratase
SCOP: PCD-like
Pterin-4-alpha-carbinolamine dehydratase in PDB entry 1f93, assembly 2, front view.
Pterin-4-alpha-carbinolamine dehydratase in PDB entry 1f93, assembly 2, side view.
Pterin-4-alpha-carbinolamine dehydratase in PDB entry 1f93, assembly 2, top view.
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Hepatocyte nuclear factor 1-alpha
Chains: E, F, G, H
Length: 32 amino acids
Theoretical weight: 3.39 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P22361 (Residues: 1-32; Coverage: 5%)
Gene names: Hnf-1, Hnf-1a, Hnf1a, Tcf1
InterPro:
SCOP: Dimerization cofactor of HNF-1 alpha
Hepatocyte nuclear factor 1-alpha in PDB entry 1f93, assembly 2, front view.
Hepatocyte nuclear factor 1-alpha in PDB entry 1f93, assembly 2, side view.
Hepatocyte nuclear factor 1-alpha in PDB entry 1f93, assembly 2, top view.
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