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STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN

X-ray diffraction
2.35Å resolution
PDB entry 1fu8 coloured by chain, front view.
PDB entry 1fu8 coloured by chain, side view.
PDB entry 1fu8 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycogen phosphorylase, muscle form
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Multimeric state: homo dimer
Accessible surface area: 58889.09 Å2
Buried surface area: 7335.32 Å2
Dissociation area: 2,500.84 Å2
Dissociation energy (ΔGdiss): 21.13 kcal/mol
Dissociation entropy (TΔSdiss): 16.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-132556

Macromolecules

Glycogen phosphorylase, muscle form
Chain: A
Length: 842 amino acids
Theoretical weight: 97.29 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P00489 (Residues: 2-843; Coverage: 100%)
Gene name: PYGM
Pfam: Carbohydrate phosphorylase
InterPro:
CATH: Glycogen Phosphorylase B;
SCOP: Oligosaccharide phosphorylase
Glycogen phosphorylase, muscle form in PDB entry 1fu8, assembly 1, front view.
Glycogen phosphorylase, muscle form in PDB entry 1fu8, assembly 1, side view.
Glycogen phosphorylase, muscle form in PDB entry 1fu8, assembly 1, top view.
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