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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT, MVV

X-ray diffraction
2Å resolution
PDB entry 1g0v coloured by chain, front view.
PDB entry 1g0v coloured by chain, side view.
PDB entry 1g0v coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease A inhibitor 3 and Saccharopepsin
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Multimeric state: hetero dimer
Accessible surface area: 14253.66 Å2
Buried surface area: 6007.85 Å2
Dissociation area: 1,498.2 Å2
Dissociation energy (ΔGdiss): 20.9 kcal/mol
Dissociation entropy (TΔSdiss): 9.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133938
Assembly 2
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Assembly Name: Protease A inhibitor 3 and Saccharopepsin
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Multimeric state: hetero tetramer
Accessible surface area: 28013.34 Å2
Buried surface area: 12516.06 Å2
Dissociation area: 3,244.91 Å2
Dissociation energy (ΔGdiss): 23.49 kcal/mol
Dissociation entropy (TΔSdiss): 33.28 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-133939
Assembly 3
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Assembly Name: Protease A inhibitor 3 and Saccharopepsin
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Multimeric state: hetero tetramer
Accessible surface area: 26120.19 Å2
Buried surface area: 14402.84 Å2
Dissociation area: 1,202.64 Å2
Dissociation energy (ΔGdiss): 0.8 kcal/mol
Dissociation entropy (TΔSdiss): 13.89 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-133939

Macromolecules

Saccharopepsin
Chain: A
Length: 329 amino acids
Theoretical weight: 35.68 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P07267 (Residues: 77-405; Coverage: 86%)
Gene names: P2585, PEP4, PHO9, PRA1, YPL154C
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
SCOP: Pepsin-like
Saccharopepsin in PDB entry 1g0v, assembly 1, front view.
Saccharopepsin in PDB entry 1g0v, assembly 1, side view.
Saccharopepsin in PDB entry 1g0v, assembly 1, top view.
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Protease A inhibitor 3
Chain: B
Length: 31 amino acids
Theoretical weight: 3.49 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P01094 (Residues: 1-31; Coverage: 46%)
Gene names: PAI3, YM8010.04C, YMR174C
Pfam: Saccharopepsin inhibitor I34
InterPro:
SCOP: Proteinase A inhibitor IA3
Protease A inhibitor 3 in PDB entry 1g0v, assembly 1, front view.
Protease A inhibitor 3 in PDB entry 1g0v, assembly 1, side view.
Protease A inhibitor 3 in PDB entry 1g0v, assembly 1, top view.
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