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ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS

X-ray diffraction
1.73Å resolution
PDB entry 1gjc coloured by chain, front view.
PDB entry 1gjc coloured by chain, side view.
PDB entry 1gjc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Urokinase-type plasminogen activator short chain A
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Multimeric state: hetero dimer
Accessible surface area: 11491.46 Å2
Buried surface area: 2176.96 Å2
Dissociation area: 507.59 Å2
Dissociation energy (ΔGdiss): 3.4 kcal/mol
Dissociation entropy (TΔSdiss): 7.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133250

Macromolecules

Urokinase-type plasminogen activator short chain A
Chain: A
Length: 23 amino acids
Theoretical weight: 2.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00749 (Residues: 156-178; Coverage: 6%)
Gene name: PLAU
SCOP: Eukaryotic proteases
Urokinase-type plasminogen activator short chain A in PDB entry 1gjc, assembly 1, front view.
Urokinase-type plasminogen activator short chain A in PDB entry 1gjc, assembly 1, side view.
Urokinase-type plasminogen activator short chain A in PDB entry 1gjc, assembly 1, top view.
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Urokinase-type plasminogen activator chain B
Chain: B
Length: 253 amino acids
Theoretical weight: 28.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00749 (Residues: 179-431; Coverage: 62%)
Gene name: PLAU
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Urokinase-type plasminogen activator chain B in PDB entry 1gjc, assembly 1, front view.
Urokinase-type plasminogen activator chain B in PDB entry 1gjc, assembly 1, side view.
Urokinase-type plasminogen activator chain B in PDB entry 1gjc, assembly 1, top view.
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