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Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan.

Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E
EMBO J 20 5342-6 (2001)
Cited: 48 times
EuropePMC logo PMID: 11574465

Abstract

Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa. Their high-affinity interaction, which is likely to contribute to BM assembly and function, is mediated by the central G2 domain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to the I-set of the IG superfamily and binds to the wall of the nidogen-1 G2 beta-barrel using beta-strands C, D and F. Nidogen-1 residues participating in the extensive interface are highly conserved, whereas the corresponding binding site on perlecan is more variable. We hypothesize that a second, as yet unidentified, activity of nidogen overlaps with perlecan binding and accounts for the unusually high degree of surface conservation in the G2 domain.

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  7. Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A. PLoS One 9 e112886 (2014)
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Reviews citing this publication (7)

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  3. Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study. Escalante T, Shannon J, Moura-da-Silva AM, Gutiérrez JM, Fox JW. Arch Biochem Biophys 455 144-153 (2006)
  4. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones JC, Lane K, Hopkinson SB, Lecuona E, Geiger RC, Dean DA, Correa-Meyer E, Gonzales M, Campbell K, Sznajder JI, Budinger S. J Cell Sci 118 2557-2566 (2005)
  5. Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases. Escalante T, Ortiz N, Rucavado A, Sanchez EF, Richardson M, Fox JW, Gutiérrez JM. PLoS One 6 e28017 (2011)
  6. Tetanus toxin entry. Nidogens are therapeutic targets for the prevention of tetanus. Bercsenyi K, Schmieg N, Bryson JB, Wallace M, Caccin P, Golding M, Zanotti G, Greensmith L, Nischt R, Schiavo G. Science 346 1118-1123 (2014)
  7. Epithelial basement membrane proteins perlecan and nidogen-2 are up-regulated in stromal cells after epithelial injury in human corneas. Torricelli AA, Marino GK, Santhanam A, Wu J, Singh A, Wilson SE. Exp Eye Res 134 33-38 (2015)
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  10. Extracellular matrices of the avian ovarian follicle. Molecular characterization of chicken perlecan. Hummel S, Osanger A, Bajari TM, Balasubramani M, Halfter W, Nimpf J, Schneider WJ. J Biol Chem 279 23486-23494 (2004)
  11. Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly. Dai J, Estrada B, Jacobs S, Sánchez-Sánchez BJ, Tang J, Ma M, Magadán-Corpas P, Pastor-Pareja JC, Martín-Bermudo MD. PLoS Genet 14 e1007483 (2018)
  12. Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures. Bechtel M, Keller MV, Bloch W, Sasaki T, Boukamp P, Zaucke F, Paulsson M, Nischt R. FASEB J 26 3637-3648 (2012)
  13. A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces. Melo R, Fieldhouse R, Melo A, Correia JD, Cordeiro MN, Gümüş ZH, Costa J, Bonvin AM, Moreira IS. Int J Mol Sci 17 E1215 (2016)
  14. Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE. Viheriälä T, Sorvari J, Ihalainen TO, Mörö A, Grönroos P, Schlie-Wolter S, Chichkov B, Skottman H, Nymark S, Ilmarinen T. Sci Rep 11 933 (2021)
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  16. Proteomic identification of membrane-associated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies. Szenasi NL, Toth E, Balogh A, Juhasz K, Karaszi K, Ozohanics O, Gelencser Z, Kiraly P, Hargitai B, Drahos L, Hupuczi P, Kovalszky I, Papp Z, Than NG. PeerJ 7 e6982 (2019)
  17. Novel internal regions of fluorescent proteins undergo divergent evolutionary patterns. Gruber DF, DeSalle R, Lienau EK, Tchernov D, Pieribone VA, Kao HT. Mol Biol Evol 26 2841-2848 (2009)
  18. Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors. Sionov RV, Lamagna C, Granot Z. Biomedicines 10 908 (2022)


Related citations provided by authors (2)

  1. Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.. Hopf M, Göhring W, Ries A, Timpl R, Hohenester E Nat Struct Biol 8 634-40 (2001)
  2. Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.. Hopf M, Göhring W, Mann K, Timpl R J Mol Biol 311 529-41 (2001)

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