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CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein

X-ray diffraction
2.5Å resolution
PDB entry 1h25 coloured by chain, front view.
PDB entry 1h25 coloured by chain, side view.
PDB entry 1h25 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero trimer (preferred)
hetero dimer
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin A2-CDK2 complex and Retinoblastoma-associated protein
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Multimeric state: hetero trimer
Accessible surface area: 23590.54 Å2
Buried surface area: 4475.36 Å2
Dissociation area: 586.3 Å2
Dissociation energy (ΔGdiss): 2.95 kcal/mol
Dissociation entropy (TΔSdiss): 7.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139027
Assembly 2
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Assembly Name: Cyclin A2-CDK2 complex
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Multimeric state: hetero dimer
Accessible surface area: 23032.8 Å2
Buried surface area: 3217.71 Å2
Dissociation area: 1,608.86 Å2
Dissociation energy (ΔGdiss): 11.5 kcal/mol
Dissociation entropy (TΔSdiss): 13.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148886
Complex Portal ID: CPX-2006

Macromolecules

Cyclin-dependent kinase 2
Chains: A, C
Length: 303 amino acids
Theoretical weight: 34.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 2 in PDB entry 1h25, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 1h25, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 1h25, assembly 1, top view.
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Cyclin-A2
Chains: B, D
Length: 259 amino acids
Theoretical weight: 29.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20248 (Residues: 174-432; Coverage: 60%)
Gene names: CCN1, CCNA, CCNA2
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin-A2 in PDB entry 1h25, assembly 1, front view.
Cyclin-A2 in PDB entry 1h25, assembly 1, side view.
Cyclin-A2 in PDB entry 1h25, assembly 1, top view.
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Retinoblastoma-associated protein
Chain: E
Length: 11 amino acids
Theoretical weight: 1.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06400 (Residues: 868-878; Coverage: 1%)
Gene name: RB1
Retinoblastoma-associated protein in PDB entry 1h25, assembly 1, front view.
Retinoblastoma-associated protein in PDB entry 1h25, assembly 1, side view.
Retinoblastoma-associated protein in PDB entry 1h25, assembly 1, top view.
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