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STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP

X-ray diffraction
2.45Å resolution
PDB entry 1hk8 coloured by chain, front view.
PDB entry 1hk8 coloured by chain, side view.
PDB entry 1hk8 coloured by chain, top view.
Source organism: Escherichia virus T4
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Anaerobic ribonucleoside-triphosphate reductase
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Multimeric state: homo dimer
Accessible surface area: 41622.54 Å2
Buried surface area: 9047.56 Å2
Dissociation area: 3,271.45 Å2
Dissociation energy (ΔGdiss): 30.75 kcal/mol
Dissociation entropy (TΔSdiss): 15.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-139363

Macromolecules

Anaerobic ribonucleoside-triphosphate reductase
Chain: A
Length: 605 amino acids
Theoretical weight: 68.06 KDa
Source organism: Escherichia virus T4
Expression system: Escherichia coli
UniProt:
  • Canonical: P07071 (Residues: 1-605; Coverage: 100%)
Gene names: 49.1, 55.11/55.13, SUNY, nrdD
Pfam: Glycine radical
InterPro:
CATH: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
SCOP: Class III anaerobic ribonucleotide reductase NRDD subunit
Anaerobic ribonucleoside-triphosphate reductase in PDB entry 1hk8, assembly 1, front view.
Anaerobic ribonucleoside-triphosphate reductase in PDB entry 1hk8, assembly 1, side view.
Anaerobic ribonucleoside-triphosphate reductase in PDB entry 1hk8, assembly 1, top view.
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