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THE STRUCTURE OF A COMPLEX OF BOVINE ALPHA-THROMBIN AND RECOMBINANT HIRUDIN AT 2.8 ANGSTROMS RESOLUTION

X-ray diffraction
2.8Å resolution
PDB entry 1hrt coloured by chain, front view.
PDB entry 1hrt coloured by chain, side view.
PDB entry 1hrt coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Activation peptide fragment 2 and Hirudin variant-1
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Multimeric state: hetero trimer
Accessible surface area: 15300.64 Å2
Buried surface area: 6447.63 Å2
Dissociation area: 1,713.84 Å2
Dissociation energy (ΔGdiss): 10.32 kcal/mol
Dissociation entropy (TΔSdiss): 11.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133168

Macromolecules

Thrombin light chain
Chain: L
Length: 49 amino acids
Theoretical weight: 5.74 KDa
Source organism: Bos taurus
Expression system: unidentified
UniProt:
  • Canonical: P00735 (Residues: 318-366; Coverage: 8%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Thrombin light chain in PDB entry 1hrt, assembly 1, front view.
Thrombin light chain in PDB entry 1hrt, assembly 1, side view.
Thrombin light chain in PDB entry 1hrt, assembly 1, top view.
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Thrombin heavy chain
Chain: H
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
Expression system: unidentified
UniProt:
  • Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Thrombin heavy chain in PDB entry 1hrt, assembly 1, front view.
Thrombin heavy chain in PDB entry 1hrt, assembly 1, side view.
Thrombin heavy chain in PDB entry 1hrt, assembly 1, top view.
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Hirudin variant-1
Chain: I
Length: 65 amino acids
Theoretical weight: 6.97 KDa
Source organism: Hirudo medicinalis
Expression system: unidentified
UniProt:
  • Canonical: P01050 (Residues: 1-65; Coverage: 100%)
Pfam: Hirudin
InterPro:
CATH: Thrombin Inhibitor (Hirudin), subunit I
SCOP: Hirudin-like
Hirudin variant-1 in PDB entry 1hrt, assembly 1, front view.
Hirudin variant-1 in PDB entry 1hrt, assembly 1, side view.
Hirudin variant-1 in PDB entry 1hrt, assembly 1, top view.
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