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STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION

X-ray diffraction
2.5Å resolution
PDB entry 1htm coloured by chain, front view.
PDB entry 1htm coloured by chain, side view.
PDB entry 1htm coloured by chain, top view.
Source organism: uncultured beta proteobacterium UMTRA-608
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin HA1 chain
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Multimeric state: hetero hexamer
Accessible surface area: 18807.51 Å2
Buried surface area: 12161.31 Å2
Dissociation area: 367.93 Å2
Dissociation energy (ΔGdiss): 4.65 kcal/mol
Dissociation entropy (TΔSdiss): 5.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137030

Macromolecules

Hemagglutinin HA1 chain
Chains: A, C, E
Length: 27 amino acids
Theoretical weight: 2.78 KDa
Source organism: uncultured beta proteobacterium UMTRA-608
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 17-43; Coverage: 5%)
Gene name: HA
Hemagglutinin HA1 chain in PDB entry 1htm, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 1htm, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 1htm, assembly 1, top view.
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Hemagglutinin HA2 chain
Chains: B, D, F
Length: 138 amino acids
Theoretical weight: 16.27 KDa
Source organism: uncultured beta proteobacterium UMTRA-608
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 383-520; Coverage: 25%)
Gene name: HA
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
SCOP: Influenza hemagglutinin (stalk)
Hemagglutinin HA2 chain in PDB entry 1htm, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 1htm, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 1htm, assembly 1, top view.
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