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LEISHMANIA MEXICANA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH INHIBITORS

X-ray diffraction
2.6Å resolution
PDB entry 1i32 coloured by chain, front view.
PDB entry 1i32 coloured by chain, side view.
PDB entry 1i32 coloured by chain, top view.
Source organism: Leishmania mexicana
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
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Multimeric state: homo tetramer
Accessible surface area: 47422.6 Å2
Buried surface area: 19729.49 Å2
Dissociation area: 5,013.96 Å2
Dissociation energy (ΔGdiss): 73.79 kcal/mol
Dissociation entropy (TΔSdiss): 16.3 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-173289
Assembly 2
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Assembly Name: Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
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Multimeric state: homo tetramer
Accessible surface area: 47427.58 Å2
Buried surface area: 19714.14 Å2
Dissociation area: 4,969.35 Å2
Dissociation energy (ΔGdiss): 78.2 kcal/mol
Dissociation entropy (TΔSdiss): 16.28 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-173289

Macromolecules

Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Chains: A, B, C, D, E, F
Length: 360 amino acids
Theoretical weight: 38.95 KDa
Source organism: Leishmania mexicana
Expression system: Escherichia coli
UniProt:
  • Canonical: Q27890 (Residues: 2-361; Coverage: 100%)
Gene name: GAPG
Pfam:
InterPro:
CATH:
SCOP:
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal in PDB entry 1i32, assembly 1, front view.
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal in PDB entry 1i32, assembly 1, side view.
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal in PDB entry 1i32, assembly 1, top view.
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