Function and Biology

HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: positive regulation of DNA-templated transcription
Cellular component: nucleus

Sequence family

Pfam Protein family (Pfam)
PF04814
Domain description: Hepatocyte nuclear factor 1 (HNF-1), N terminus
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
The deposited structure of PDB entry 1ic8 contains 2 copies of Pfam domain PF04814 (Hepatocyte nuclear factor 1 (HNF-1), N terminus) in Hepatocyte nuclear factor 1-alpha. Showing 1 copy in chain D [auth B].

InterPro InterPro annotations
IPR001356
Domain description: Homeodomain
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
IPR010982
Domain description: Lambda repressor-like, DNA-binding domain superfamily
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
IPR009057
Domain description: Homedomain-like superfamily
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
IPR044869
Domain description: HNF-1, POU-specific (POUs) atypical domain
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
IPR006899
Domain description: Hepatocyte nuclear factor 1, N-terminal
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
IPR039066
Domain description: Hepatocyte nuclear factor 1
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha

Structure domains

CATH CATH domains
1.10.10.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Homeodomain-like
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
The deposited structure of PDB entry 1ic8 contains 2 copies of CATH domain 1.10.10.60 (Arc Repressor Mutant, subunit A) in Hepatocyte nuclear factor 1-alpha. Showing 1 copy in chain D [auth B].
1.10.260.40
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: 434 Repressor (Amino-terminal Domain)
Homology: lambda repressor-like DNA-binding domains
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
The deposited structure of PDB entry 1ic8 contains 2 copies of CATH domain 1.10.260.40 (434 Repressor (Amino-terminal Domain)) in Hepatocyte nuclear factor 1-alpha. Showing 1 copy in chain D [auth B].
SCOP SCOP annotations
46690
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: Homeodomain-like
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
The deposited structure of PDB entry 1ic8 contains 2 copies of SCOP domain 46690 (Homeodomain) in Hepatocyte nuclear factor 1-alpha. Showing 1 copy in chain D [auth B].
47414
Class: All alpha proteins
Fold: lambda repressor-like DNA-binding domains
Superfamily: lambda repressor-like DNA-binding domains
Occurring in:
  1. Hepatocyte nuclear factor 1-alpha
The deposited structure of PDB entry 1ic8 contains 2 copies of SCOP domain 47414 (POU-specific domain) in Hepatocyte nuclear factor 1-alpha. Showing 1 copy in chain D [auth B].