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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

X-ray diffraction
2.4Å resolution
PDB entry 1iny coloured by chain, front view.
PDB entry 1iny coloured by chain, side view.
PDB entry 1iny coloured by chain, top view.
Source organism: Influenza A virus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neuraminidase
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Multimeric state: homo tetramer
Accessible surface area: 49724.44 Å2
Buried surface area: 26160.7 Å2
Dissociation area: 8,704.6 Å2
Dissociation energy (ΔGdiss): -17.81 kcal/mol
Dissociation entropy (TΔSdiss): 45.13 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-137058

Macromolecules

Neuraminidase
Chain: A
Length: 388 amino acids
Theoretical weight: 43.75 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: P03472 (Residues: 83-470; Coverage: 83%)
Gene name: NA
Pfam: Neuraminidase
InterPro:
CATH: Neuraminidase
SCOP: Sialidases (neuraminidases)
Neuraminidase in PDB entry 1iny, assembly 1, front view.
Neuraminidase in PDB entry 1iny, assembly 1, side view.
Neuraminidase in PDB entry 1iny, assembly 1, top view.
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