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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GTP

X-ray diffraction
2Å resolution
PDB entry 1ipc coloured by chain, front view.
PDB entry 1ipc coloured by chain, side view.
PDB entry 1ipc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 4E
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Multimeric state: monomeric
Accessible surface area: 10493.77 Å2
Buried surface area: 619.49 Å2
Dissociation area: 309.74 Å2
Dissociation energy (ΔGdiss): -0.68 kcal/mol
Dissociation entropy (TΔSdiss): 5.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139166
Monomeric assembly 1 of PDB entry 1ipc coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 1ipc coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 1ipc coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 95%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 1
Symmetry : None
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Eukaryotic translation initiation factor 4E
Chain: A
Length: 217 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06730 (Residues: 1-217; Coverage: 100%)
Gene names: EIF4E, EIF4EL1, EIF4F
Pfam: Eukaryotic initiation factor 4E
InterPro:
CATH: RNA Cap, Translation Initiation Factor Eif4e
SCOP: Translation initiation factor eIF4e
Eukaryotic translation initiation factor 4E in PDB entry 1ipc, assembly 1, front view.
Eukaryotic translation initiation factor 4E in PDB entry 1ipc, assembly 1, side view.
Eukaryotic translation initiation factor 4E in PDB entry 1ipc, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P06730  
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