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STRUCTURE OF HUMAN ISOVALERYL-COA DEHYDROGENASE AT 2.6 ANGSTROMS RESOLUTION: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY

X-ray diffraction
2.6Å resolution
PDB entry 1ivh coloured by chain, front view.
PDB entry 1ivh coloured by chain, side view.
PDB entry 1ivh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Isovaleryl-CoA dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 46949.78 Å2
Buried surface area: 26505.0 Å2
Dissociation area: 3,742.17 Å2
Dissociation energy (ΔGdiss): 47.6 kcal/mol
Dissociation entropy (TΔSdiss): 16.01 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-150745

Macromolecules

Isovaleryl-CoA dehydrogenase, mitochondrial
Chains: A, B, C, D
Length: 394 amino acids
Theoretical weight: 43.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26440 (Residues: 33-426; Coverage: 93%)
Gene name: IVD
Pfam:
InterPro:
CATH:
SCOP:
Isovaleryl-CoA dehydrogenase, mitochondrial in PDB entry 1ivh, assembly 1, front view.
Isovaleryl-CoA dehydrogenase, mitochondrial in PDB entry 1ivh, assembly 1, side view.
Isovaleryl-CoA dehydrogenase, mitochondrial in PDB entry 1ivh, assembly 1, top view.
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