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Solution structure of tyrosyl-tRNA synthetase C-terminal domain.

Source organism: Geobacillus stearothermophilus
Biochemical function: tyrosine-tRNA ligase activity
Biological process: not assigned
Cellular component: not assigned

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EC 6.1.1.1: Tyrosine--tRNA ligase

Reaction catalysed:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)
Systematic name:
L-tyrosine:tRNA(Tyr) ligase (AMP-forming)
Alternative Name(s):
  • L-tyrosine-tRNA(Tyr) ligase (AMP-forming)
  • Tyrosine tRNA synthetase
  • Tyrosine translase
  • Tyrosine-transfer RNA ligase
  • Tyrosine-transfer ribonucleate synthetase
  • Tyrosyl-tRNA ligase
  • Tyrosyl-tRNA synthetase
  • Tyrosyl-transfer RNA synthetase
  • Tyrosyl-transfer ribonucleate synthetase
  • Tyrosyl-transfer ribonucleic acid synthetase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF22421
Domain description: Tyrosine--tRNA ligase SYY-like C-terminal domain
Occurring in:
  1. Tyrosine--tRNA ligase

InterPro InterPro annotations
IPR002942
Domain description: RNA-binding S4 domain
Occurring in:
  1. Tyrosine--tRNA ligase
IPR024088
Domain description: Tyrosine-tRNA ligase, bacterial-type
Occurring in:
  1. Tyrosine--tRNA ligase
IPR036986
Domain description: RNA-binding S4 domain superfamily
Occurring in:
  1. Tyrosine--tRNA ligase

Structure domain

CATH CATH domain
3.10.290.10
Class: Alpha Beta
Architecture: Roll
Topology: Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A
Homology: RNA-binding S4 domain
Occurring in:
  1. Tyrosine--tRNA ligase
The deposited structure of PDB entry 1jh3 contains 1 copy of CATH domain 3.10.290.10 (Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A) in Tyrosine--tRNA ligase. Showing 1 copy in chain A.
SCOP SCOP annotation
75465
Class: Alpha and beta proteins (a+b)
Fold: Alpha-L RNA-binding motif
Superfamily: Alpha-L RNA-binding motif
Occurring in:
  1. Tyrosine--tRNA ligase
The deposited structure of PDB entry 1jh3 contains 1 copy of SCOP domain 75465 (Tyrosyl-tRNA synthetase (TyrRS), C-terminal domain) in Tyrosine--tRNA ligase. Showing 1 copy in chain A.

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