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Gly156Asp mutant of Human UroD, human uroporphyrinogen III decarboxylase

X-ray diffraction
2.2Å resolution
PDB entry 1jpk coloured by chain, front view.
PDB entry 1jpk coloured by chain, side view.
PDB entry 1jpk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Uroporphyrinogen decarboxylase
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Multimeric state: homo dimer
Accessible surface area: 26735.99 Å2
Buried surface area: 2420.22 Å2
Dissociation area: 1,210.11 Å2
Dissociation energy (ΔGdiss): 1.27 kcal/mol
Dissociation entropy (TΔSdiss): 13.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138879
Homo dimeric assembly 1 of PDB entry 1jpk coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 1jpk coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 1jpk coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 2
Symmetry : C2
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3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : Interface geometry is similar to that of 3cyv_1 (47% id)

Macromolecules

Uroporphyrinogen decarboxylase
Chain: A
Length: 388 amino acids
Theoretical weight: 43.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06132 (Residues: 1-367; Coverage: 100%)
Gene name: UROD
Pfam: Uroporphyrinogen decarboxylase (URO-D)
InterPro:
CATH: TIM Barrel
SCOP: Uroporphyrinogen decarboxylase, UROD
Uroporphyrinogen decarboxylase in PDB entry 1jpk, assembly 1, front view.
Uroporphyrinogen decarboxylase in PDB entry 1jpk, assembly 1, side view.
Uroporphyrinogen decarboxylase in PDB entry 1jpk, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P06132  
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