PDB 1jrr biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

1jrr › Structure analysis

HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2.[LOOP (66-98) DELETIONMUTANT] COMPLEXED WITH PEPTIDE MIMIckING THE REACTIVE CENTER LOOP

X-ray diffraction

1.6Å resolution

Source organism: Homo sapiens

Assembly composition:

hetero dimer (preferred)

Entry contents: 2 distinct polypeptide molecules

Assembly 1 (preferred)

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Assembly Name: Plasminogen activator inhibitor 2

Multimeric state: hetero dimer

Accessible surface area: 15656.33 Å²

Buried surface area: 2934.12 Å²

Dissociation area: 1,353.55 Å²

Dissociation energy (ΔG^diss): 23.83 kcal/mol

Dissociation entropy (TΔS^diss): 8.45 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-138522

Chain: A
Length: 382 amino acids
Theoretical weight: 43.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P05120 (Residues: 1-415; Coverage: 92%)

Gene names: PAI2, PLANH2, SERPINB2
Pfam: Serpin (serine protease inhibitor)
InterPro:

CATH:

SCOP: Serpins

FASTA Sequence


    >pdb|1jrr|A

MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGAAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP

PDBe-KB: UniProt Coverage View: P05120

Plasminogen activator inhibitor 2

Chain: P
Length: 15 amino acids
Theoretical weight: 1.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:

Canonical: P05120 (Residues: 367-380; Coverage: 3%)

Gene names: PAI2, PLANH2, SERPINB2

Molecule details ›

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FASTA (Protein chains P)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST P05120 (UniProt)

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	Secondary structure
	Flexibility predictions
	Early folding residue predictions
	Ligand binding sites
	Interaction interfaces
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	UniProt
	Chains
	Secondary structure
	Flexibility predictions
	Interaction interfaces

Protein Data Bank in Europe

HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2.[LOOP (66-98) DELETIONMUTANT] COMPLEXED WITH PEPTIDE MIMIckING THE REACTIVE CENTER LOOP