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Degenerate interfaces in antigen-antibody complexes

X-ray diffraction
2.1Å resolution
PDB entry 1jtt coloured by chain, front view.
PDB entry 1jtt coloured by chain, side view.
PDB entry 1jtt coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lysozyme C and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 11475.3 Å2
Buried surface area: 3823.5 Å2
Dissociation area: 838.69 Å2
Dissociation energy (ΔGdiss): 4.17 kcal/mol
Dissociation entropy (TΔSdiss): 11.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-226695
Assembly 2
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Assembly Name: Lysozyme C and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 12194.6 Å2
Buried surface area: 3107.04 Å2
Dissociation area: 454.01 Å2
Dissociation energy (ΔGdiss): -4.23 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-226695

Macromolecules

Vh Single-Domain Antibody
Chain: A
Length: 133 amino acids
Theoretical weight: 14 KDa
Source organism: Camelus dromedarius
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
SCOP: V set domains (antibody variable domain-like)
Vh Single-Domain Antibody in PDB entry 1jtt, assembly 1, front view.
Vh Single-Domain Antibody in PDB entry 1jtt, assembly 1, side view.
Vh Single-Domain Antibody in PDB entry 1jtt, assembly 1, top view.
1133102030405060708090100110120130
 
50100
Chains
RSRZ Outlier Chain A (auth A)
Chain A (auth A)
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Lysozyme C
Chain: L
Length: 129 amino acids
Theoretical weight: 14.33 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P00698 (Residues: 19-147; Coverage: 100%)
Gene name: LYZ
Pfam: C-type lysozyme/alpha-lactalbumin family
InterPro:
CATH: Lysozyme
SCOP: C-type lysozyme
Lysozyme C in PDB entry 1jtt, assembly 1, front view.
Lysozyme C in PDB entry 1jtt, assembly 1, side view.
Lysozyme C in PDB entry 1jtt, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P00698  
1129102030405060708090100110120
 
50100
UniProt
P00698
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation
Molecule details ›

Search similar proteins

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