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Crystals of Peptide Deformylase from Plasmodium falciparum with Ten Subunits per Asymmetric Unit Reveal Critical Characteristics of the Active Site for Drug Design

X-ray diffraction
2.8Å resolution
PDB entry 1jym coloured by chain, front view.
PDB entry 1jym coloured by chain, side view.
PDB entry 1jym coloured by chain, top view.
Source organism: Plasmodium falciparum
Assembly composition:
homo decamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptide deformylase
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Multimeric state: homo decamer
Accessible surface area: 91247.63 Å2
Buried surface area: 11370.36 Å2
Dissociation area: 5,046.36 Å2
Dissociation energy (ΔGdiss): -56.9 kcal/mol
Dissociation entropy (TΔSdiss): 116.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-184654

Macromolecules

Peptide deformylase
Chains: A, B, C, D, E, F, G, H, I, J
Length: 183 amino acids
Theoretical weight: 21.82 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I372 (Residues: 63-239; Coverage: 73%)
Gene name: PF3D7_0907900
Pfam: Polypeptide deformylase
InterPro:
CATH: Peptide deformylase
SCOP: Peptide deformylase
Peptide deformylase in PDB entry 1jym, assembly 1, front view.
Peptide deformylase in PDB entry 1jym, assembly 1, side view.
Peptide deformylase in PDB entry 1jym, assembly 1, top view.
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