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SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES

X-ray diffraction
2Å resolution
PDB entry 1kjh coloured by chain, front view.
PDB entry 1kjh coloured by chain, side view.
PDB entry 1kjh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: hetero trimer
Accessible surface area: 9020.83 Å2
Buried surface area: 6018.81 Å2
Dissociation area: 2,348.97 Å2
Dissociation energy (ΔGdiss): 34.5 kcal/mol
Dissociation entropy (TΔSdiss): 11.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136844

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.8 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P03369 (Residues: 491-589; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
SCOP: Retroviral protease (retropepsin)
Protease in PDB entry 1kjh, assembly 1, front view.
Protease in PDB entry 1kjh, assembly 1, side view.
Protease in PDB entry 1kjh, assembly 1, top view.
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p15
Chain: P
Length: 10 amino acids
Theoretical weight: 1.19 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Not provided
UniProt:
  • Canonical: P03366 (Residues: 1155-1164; Coverage: 1%)
Gene name: gag-pol
p15 in PDB entry 1kjh, assembly 1, front view.
p15 in PDB entry 1kjh, assembly 1, side view.
p15 in PDB entry 1kjh, assembly 1, top view.
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