› 1l0l

X-ray diffraction
2.35Å resolution

structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

Released:
DOI: 10.2210/pdb1l0l/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1l0l coloured by chain, front view.
PDB entry 1l0l coloured by chain, side view.
PDB entry 1l0l coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition.
Gao X, Wen X, Yu C, Esser L, Tsao S, Quinn B, Zhang L, Yu L, Xia D
Biochemistry 41 11692-702 (2002)
PMID: 12269811

Function and Biology Details

Reaction catalysed: 
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero undecamer (preferred)
hetero 22-mer
PDBe Complex ID:
PDB-CPX-132255 (preferred)
Entry contents:
11 distinct polypeptide molecules
Macromolecules (11 distinct):
Cytochrome b-c1 complex subunit 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 49.27 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P31800 (Residues: 35-480; Coverage: 93%)
Gene name: UQCRC1
Sequence domains:
Structure domains: Metalloenzyme, LuxS/M16 peptidase-like
Cytochrome b-c1 complex subunit 2, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 439 amino acids
Theoretical weight: 46.58 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23004 (Residues: 15-453; Coverage: 97%)
Gene name: UQCRC2
Sequence domains:
Structure domains: Metalloenzyme, LuxS/M16 peptidase-like
Cytochrome b Chain: C
Cytochrome c1, heme protein, mitochondrial Chain: D
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chain: E
Cytochrome b-c1 complex subunit 7 Chain: F
Cytochrome b-c1 complex subunit 8 Chain: G
Cytochrome b-c1 complex subunit 6, mitochondrial Chain: H
Cytochrome b-c1 complex subunit 9 Chain: I
Cytochrome b-c1 complex subunit 9 Chain: J
Cytochrome b-c1 complex subunit 10 Chain: K

Ligands and Environments


Cofactor: Ligand HEM 3 x HEM
2 bound ligands:
Ligand FMX 1 x FMX
Ligand FES 1 x FES
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: I4122
Unit cell:
a: 154.094Å b: 154.094Å c: 591.839Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.259 0.306

Quick links

Citations

16 review citations

The ATP synthase: the understood, the uncertain and the unknown.
Walker JE. (2013)
15 more

19 mentions without citation

Metabolism.
Judge et al. (2020)
18 more