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TRAF6-CD40 Complex

X-ray diffraction
1.8Å resolution
PDB entry 1lb6 coloured by chain, front view.
PDB entry 1lb6 coloured by chain, side view.
PDB entry 1lb6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TNF receptor-associated factor 6 and Tumor necrosis factor receptor superfamily member 5
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Multimeric state: hetero dimer
Accessible surface area: 9041.53 Å2
Buried surface area: 1146.27 Å2
Dissociation area: 573.13 Å2
Dissociation energy (ΔGdiss): 0.28 kcal/mol
Dissociation entropy (TΔSdiss): 7.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150616

Macromolecules

TNF receptor-associated factor 6
Chain: A
Length: 160 amino acids
Theoretical weight: 18.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4K3 (Residues: 347-504; Coverage: 30%)
Gene names: RNF85, TRAF6
Pfam: TRAF/meprin, MATH domain
InterPro:
CATH: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
SCOP: MATH domain
TNF receptor-associated factor 6 in PDB entry 1lb6, assembly 1, front view.
TNF receptor-associated factor 6 in PDB entry 1lb6, assembly 1, side view.
TNF receptor-associated factor 6 in PDB entry 1lb6, assembly 1, top view.
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Tumor necrosis factor receptor superfamily member 5
Chain: B
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25942 (Residues: 230-238; Coverage: 4%)
Gene names: CD40, TNFRSF5
Tumor necrosis factor receptor superfamily member 5 in PDB entry 1lb6, assembly 1, front view.
Tumor necrosis factor receptor superfamily member 5 in PDB entry 1lb6, assembly 1, side view.
Tumor necrosis factor receptor superfamily member 5 in PDB entry 1lb6, assembly 1, top view.
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