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CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B

X-ray diffraction
2.3Å resolution
PDB entry 1lez coloured by chain, front view.
PDB entry 1lez coloured by chain, side view.
PDB entry 1lez coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 14 and Dual specificity mitogen-activated protein kinase kinase 3
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Multimeric state: hetero dimer
Accessible surface area: 17233.86 Å2
Buried surface area: 962.47 Å2
Dissociation area: 481.23 Å2
Dissociation energy (ΔGdiss): 4.28 kcal/mol
Dissociation entropy (TΔSdiss): 6.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126711

Macromolecules

Mitogen-activated protein kinase 14
Chain: A
Length: 360 amino acids
Theoretical weight: 41.34 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Mitogen-activated protein kinase 14 in PDB entry 1lez, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 1lez, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 1lez, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P47811  
136050100150200250300350
 
100200300
UniProt
P47811
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Dual specificity mitogen-activated protein kinase kinase 3
Chain: B
Length: 18 amino acids
Theoretical weight: 2.07 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: O09110 (Residues: 15-32; Coverage: 5%)
Gene names: Map2k3, Mkk3, Prkmk3
Dual specificity mitogen-activated protein kinase kinase 3 in PDB entry 1lez, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 3 in PDB entry 1lez, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 3 in PDB entry 1lez, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O09110  
11824681012141618
 
51015SKGKSKRKKDLRISCNSK
UniProt
O09110
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Flexibility predictions
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