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Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization

X-ray diffraction
2.38Å resolution
PDB entry 1lj2 coloured by chain, front view.
PDB entry 1lj2 coloured by chain, side view.
PDB entry 1lj2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 4 gamma 1 and Non-structural protein 3
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Multimeric state: hetero tetramer
Accessible surface area: 14083.94 Å2
Buried surface area: 9685.83 Å2
Dissociation area: 1,736.15 Å2
Dissociation energy (ΔGdiss): 15.95 kcal/mol
Dissociation entropy (TΔSdiss): 18.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-137115

Macromolecules

Non-structural protein 3
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.84 KDa
Source organism: Simian rotavirus A/SA11
Expression system: Escherichia coli
UniProt:
  • Canonical: P03536 (Residues: 206-315; Coverage: 35%)
InterPro: Rotavirus non-structural protein NSP3
CATH: Nonstructural RNA-binding protein
SCOP: NSP3 C-terminal domain, NS34
Non-structural protein 3 in PDB entry 1lj2, assembly 1, front view.
Non-structural protein 3 in PDB entry 1lj2, assembly 1, side view.
Non-structural protein 3 in PDB entry 1lj2, assembly 1, top view.
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Eukaryotic translation initiation factor 4 gamma 1
Chains: C, D
Length: 28 amino acids
Theoretical weight: 3.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q04637 (Residues: 172-199; Coverage: 2%)
Gene names: EIF4F, EIF4G, EIF4G1, EIF4GI
Eukaryotic translation initiation factor 4 gamma 1 in PDB entry 1lj2, assembly 1, front view.
Eukaryotic translation initiation factor 4 gamma 1 in PDB entry 1lj2, assembly 1, side view.
Eukaryotic translation initiation factor 4 gamma 1 in PDB entry 1lj2, assembly 1, top view.
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