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Crystal Structure of the S137A mutant of L-3-Hydroxyacyl-CoA Dehydrogenase in Complex with NAD

X-ray diffraction
2.6Å resolution
PDB entry 1lso coloured by chain, front view.
PDB entry 1lso coloured by chain, side view.
PDB entry 1lso coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 24940.35 Å2
Buried surface area: 5403.31 Å2
Dissociation area: 1,602.63 Å2
Dissociation energy (ΔGdiss): 17.65 kcal/mol
Dissociation entropy (TΔSdiss): 13.65 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172593

Macromolecules

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Chains: A, B
Length: 302 amino acids
Theoretical weight: 32.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16836 (Residues: 13-314; Coverage: 96%)
Gene names: HAD, HAD1, HADH, HADHSC, SCHAD
Pfam:
InterPro:
CATH:
SCOP:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial in PDB entry 1lso, assembly 1, front view.
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial in PDB entry 1lso, assembly 1, side view.
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial in PDB entry 1lso, assembly 1, top view.
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