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Plasmodium Falciparum Triosephosphate Isomerase (PfTIM)-Phosphoglycolate complex

X-ray diffraction
1.9Å resolution
PDB entry 1lyx coloured by chain, front view.
PDB entry 1lyx coloured by chain, side view.
PDB entry 1lyx coloured by chain, top view.
Source organism: Plasmodium falciparum
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Triosephosphate isomerase
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Multimeric state: homo dimer
Accessible surface area: 22550.95 Å2
Buried surface area: 1257.69 Å2
Dissociation area: 254.28 Å2
Dissociation energy (ΔGdiss): -9.66 kcal/mol
Dissociation entropy (TΔSdiss): 12.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170466
Assembly 2
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Assembly Name: Triosephosphate isomerase
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Multimeric state: homo dimer
Accessible surface area: 19726.58 Å2
Buried surface area: 4082.36 Å2
Dissociation area: 1,667.95 Å2
Dissociation energy (ΔGdiss): 19.34 kcal/mol
Dissociation entropy (TΔSdiss): 13.15 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170466

Macromolecules

Triosephosphate isomerase
Chain: A
Length: 248 amino acids
Theoretical weight: 28 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07412 (Residues: 1-248; Coverage: 100%)
Gene name: TPI
Pfam: Triosephosphate isomerase
InterPro:
CATH: Aldolase class I
SCOP: Triosephosphate isomerase (TIM)
Triosephosphate isomerase in PDB entry 1lyx, assembly 1, front view.
Triosephosphate isomerase in PDB entry 1lyx, assembly 1, side view.
Triosephosphate isomerase in PDB entry 1lyx, assembly 1, top view.
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