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Mistletoe Lectin I from Viscum album in Complex with Adenine Monophosphate. Crystal Structure at 1.9 A Resolution

X-ray diffraction
1.89Å resolution
PDB entry 1m2t coloured by chain, front view.
PDB entry 1m2t coloured by chain, side view.
PDB entry 1m2t coloured by chain, top view.
Source organism: Viscum album
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-galactoside-specific lectin 1 chain B
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Multimeric state: hetero dimer
Accessible surface area: 19869.04 Å2
Buried surface area: 7234.17 Å2
Dissociation area: 1,661.02 Å2
Dissociation energy (ΔGdiss): 10.42 kcal/mol
Dissociation entropy (TΔSdiss): 12.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160520

Macromolecules

Beta-galactoside-specific lectin 1 chain A isoform 1
Chain: A
Length: 254 amino acids
Theoretical weight: 27.82 KDa
Source organism: Viscum album
UniProt:
  • Canonical: P81446 (Residues: 34-287; Coverage: 48%)
Pfam: Ribosome inactivating protein
InterPro:
CATH:
SCOP: Plant cytotoxins
Beta-galactoside-specific lectin 1 chain A isoform 1 in PDB entry 1m2t, assembly 1, front view.
Beta-galactoside-specific lectin 1 chain A isoform 1 in PDB entry 1m2t, assembly 1, side view.
Beta-galactoside-specific lectin 1 chain A isoform 1 in PDB entry 1m2t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P81446  
125420406080100120140160180200220240
 
100200
UniProt
P81446
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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Beta-galactoside-specific lectin 1 chain B
Chain: B
Length: 263 amino acids
Theoretical weight: 28.57 KDa
Source organism: Viscum album
UniProt:
  • Canonical: P81446 (Residues: 302-510, 512-563; Coverage: 49%)
Pfam: Ricin-type beta-trefoil lectin domain
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
SCOP: Ricin B-like
Beta-galactoside-specific lectin 1 chain B in PDB entry 1m2t, assembly 1, front view.
Beta-galactoside-specific lectin 1 chain B in PDB entry 1m2t, assembly 1, side view.
Beta-galactoside-specific lectin 1 chain B in PDB entry 1m2t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P81446  
126320406080100120140160180200220240260
 
100200
UniProt
P81446
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar proteins

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