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Modular recognition of RNA by a human pumilio-homology domain.

Wang X, McLachlan J, Zamore PD, Hall TM
Cell 110 501-12 (2002)
Related entries: 1m8x, 1m8y

Cited: 338 times
EuropePMC logo PMID: 12202039

Abstract

Puf proteins are developmental regulators that control mRNA stability and translation by binding sequences in the 3' untranslated regions of their target mRNAs. We have determined the structure of the RNA binding domain of the human Puf protein, Pumilio1, bound to a high-affinity RNA ligand. The RNA binds the concave surface of the molecule, where each of the protein's eight repeats makes contacts with a different RNA base via three amino acid side chains at conserved positions. We have mutated these three side chains in one repeat, thereby altering the sequence specificity of Pumilio1. Thus, the high affinity and specificity of the PUM-HD for RNA is achieved using multiple copies of a simple repeated motif.

Reviews - 1m8w mentioned but not cited (1)

  1. How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms. Corley M, Burns MC, Yeo GW. Mol Cell 78 9-29 (2020)

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