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CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-19 RNA

X-ray diffraction
2.2Å resolution
PDB entry 1m8w coloured by chain, front view.
PDB entry 1m8w coloured by chain, side view.
PDB entry 1m8w coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
4 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pumilio homolog 1 and RNA
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Multimeric state: hetero trimer
PDBe Complex ID: PDB-CPX-219596
Assembly 2
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Assembly Name: Pumilio homolog 1 and RNA
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Multimeric state: hetero trimer
PDBe Complex ID: PDB-CPX-219597

Macromolecules

Pumilio homolog 1
Chains: A, B
Length: 349 amino acids
Theoretical weight: 40.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14671 (Residues: 828-1176; Coverage: 29%)
Gene names: KIAA0099, PUM1, PUMH1
Pfam: Pumilio-family RNA binding repeat
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: Pumilio repeat
Pumilio homolog 1 in PDB entry 1m8w, assembly 1, front view.
Pumilio homolog 1 in PDB entry 1m8w, assembly 1, side view.
Pumilio homolog 1 in PDB entry 1m8w, assembly 1, top view.
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RNA chain C
Name: 5'-R(P*UP*UP*GP*UP*AP*UP*AP*U)-3'
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.49 KDa
5'-R(P*UP*UP*GP*UP*AP*UP*AP*U)-3' in PDB entry 1m8w, assembly 1, front view.
5'-R(P*UP*UP*GP*UP*AP*UP*AP*U)-3' in PDB entry 1m8w, assembly 1, side view.
5'-R(P*UP*UP*GP*UP*AP*UP*AP*U)-3' in PDB entry 1m8w, assembly 1, top view.
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RNA chain D
Name: 5'-R(P*UP*GP*UP*AP*UP*AP*U)-3'
Representative chains: D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 7 nucleotides
Theoretical weight: 2.18 KDa
5'-R(P*UP*GP*UP*AP*UP*AP*U)-3' in PDB entry 1m8w, assembly 2, front view.
5'-R(P*UP*GP*UP*AP*UP*AP*U)-3' in PDB entry 1m8w, assembly 2, side view.
5'-R(P*UP*GP*UP*AP*UP*AP*U)-3' in PDB entry 1m8w, assembly 2, top view.
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RNA chain E
Name: 5'-R(P*UP*UP*GP*UP*CP*CP*AP*G)-3'
Representative chains: E
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.5 KDa
5'-R(P*UP*UP*GP*UP*CP*CP*AP*G)-3' in PDB entry 1m8w, assembly 1, front view.
5'-R(P*UP*UP*GP*UP*CP*CP*AP*G)-3' in PDB entry 1m8w, assembly 1, side view.
5'-R(P*UP*UP*GP*UP*CP*CP*AP*G)-3' in PDB entry 1m8w, assembly 1, top view.
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RNA chain F
Name: 5'-R(P*UP*GP*UP*CP*CP*AP*G)-3'
Representative chains: F
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 7 nucleotides
Theoretical weight: 2.2 KDa
5'-R(P*UP*GP*UP*CP*CP*AP*G)-3' in PDB entry 1m8w, assembly 2, front view.
5'-R(P*UP*GP*UP*CP*CP*AP*G)-3' in PDB entry 1m8w, assembly 2, side view.
5'-R(P*UP*GP*UP*CP*CP*AP*G)-3' in PDB entry 1m8w, assembly 2, top view.
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