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complex structure of human GAR Tfase and substrate beta-GAR

X-ray diffraction
2.23Å resolution
PDB entry 1men coloured by chain, front view.
PDB entry 1men coloured by chain, side view.
PDB entry 1men coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Trifunctional purine biosynthetic protein adenosine-3
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Multimeric state: monomeric
Accessible surface area: 9702.97 Å2
Buried surface area: 614.26 Å2
Dissociation area: 307.13 Å2
Dissociation energy (ΔGdiss): 5.27 kcal/mol
Dissociation entropy (TΔSdiss): 3.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149522
Assembly 2
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Assembly Name: Trifunctional purine biosynthetic protein adenosine-3
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Multimeric state: monomeric
Accessible surface area: 9724.54 Å2
Buried surface area: 627.45 Å2
Dissociation area: 313.73 Å2
Dissociation energy (ΔGdiss): 6.39 kcal/mol
Dissociation entropy (TΔSdiss): 3.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149522
Assembly 3
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Assembly Name: Trifunctional purine biosynthetic protein adenosine-3
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Multimeric state: monomeric
Accessible surface area: 9865.1 Å2
Buried surface area: 613.36 Å2
Dissociation area: 306.68 Å2
Dissociation energy (ΔGdiss): 5.86 kcal/mol
Dissociation entropy (TΔSdiss): 3.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149522

Macromolecules

Trifunctional purine biosynthetic protein adenosine-3
Chains: A, B, C
Length: 223 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22102 (Residues: 810-1010; Coverage: 20%)
Gene names: GART, PGFT, PRGS
Pfam: Formyl transferase
InterPro:
CATH: Formyl transferase, N-terminal domain
SCOP: Formyltransferase
Trifunctional purine biosynthetic protein adenosine-3 in PDB entry 1men, assembly 1, front view.
Trifunctional purine biosynthetic protein adenosine-3 in PDB entry 1men, assembly 1, side view.
Trifunctional purine biosynthetic protein adenosine-3 in PDB entry 1men, assembly 1, top view.
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