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STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX

X-ray diffraction
3.5Å resolution
PDB entry 1mje coloured by chain, front view.
PDB entry 1mje coloured by chain, side view.
PDB entry 1mje coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Breast cancer type 2 susceptibility protein homolog and 26S proteasome complex subunit SEM1 and DNA
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Multimeric state: hetero trimer
Accessible surface area: 33147.61 Å2
Buried surface area: 7236.74 Å2
Dissociation area: 931.85 Å2
Dissociation energy (ΔGdiss): 4.81 kcal/mol
Dissociation entropy (TΔSdiss): 8.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114184

Macromolecules

26S proteasome complex subunit SEM1
Chain: B
Length: 70 amino acids
Theoretical weight: 8.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60896 (Residues: 1-70; Coverage: 100%)
Gene names: C7orf76, DSS1, SEM1, SHFDG1, SHFM1
Pfam: DSS1/SEM1 family
InterPro: DSS1/SEM1
26S proteasome complex subunit SEM1 in PDB entry 1mje, assembly 1, front view.
26S proteasome complex subunit SEM1 in PDB entry 1mje, assembly 1, side view.
26S proteasome complex subunit SEM1 in PDB entry 1mje, assembly 1, top view.
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Breast cancer type 2 susceptibility protein homolog
Chain: A
Length: 649 amino acids
Theoretical weight: 72.98 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P97929 (Residues: 2378-3113; Coverage: 20%)
Gene names: Brca2, Fancd1
Pfam:
InterPro:
CATH: Nucleic acid-binding proteins
SCOP:
Breast cancer type 2 susceptibility protein homolog in PDB entry 1mje, assembly 1, front view.
Breast cancer type 2 susceptibility protein homolog in PDB entry 1mje, assembly 1, side view.
Breast cancer type 2 susceptibility protein homolog in PDB entry 1mje, assembly 1, top view.
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DNA chain C
Name: 5'-D(P*TP*TP*TP*TP*TP*T)-3'
Representative chains: C
Length: 6 nucleotides
Theoretical weight: 1.78 KDa
5'-D(P*TP*TP*TP*TP*TP*T)-3' in PDB entry 1mje, assembly 1, front view.
5'-D(P*TP*TP*TP*TP*TP*T)-3' in PDB entry 1mje, assembly 1, side view.
5'-D(P*TP*TP*TP*TP*TP*T)-3' in PDB entry 1mje, assembly 1, top view.
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