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Human Factor Inhibiting HIF (FIH1)

X-ray diffraction
2.2Å resolution
PDB entry 1mze coloured by chain, front view.
PDB entry 1mze coloured by chain, side view.
PDB entry 1mze coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxia-inducible factor 1-alpha inhibitor
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Multimeric state: homo dimer
Accessible surface area: 33327.54 Å2
Buried surface area: 2289.54 Å2
Dissociation area: 597.83 Å2
Dissociation energy (ΔGdiss): -6.78 kcal/mol
Dissociation entropy (TΔSdiss): 13.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192661
Assembly 2
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Assembly Name: Hypoxia-inducible factor 1-alpha inhibitor
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Multimeric state: homo dimer
Accessible surface area: 31285.16 Å2
Buried surface area: 4335.89 Å2
Dissociation area: 1,620.72 Å2
Dissociation energy (ΔGdiss): 19.87 kcal/mol
Dissociation entropy (TΔSdiss): 13.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-192661

Macromolecules

Hypoxia-inducible factor 1-alpha inhibitor
Chain: A
Length: 351 amino acids
Theoretical weight: 40.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NWT6 (Residues: 1-349; Coverage: 100%)
Gene names: FIH1, HIF1AN
Pfam: Cupin-like domain
InterPro:
CATH:
SCOP: Hypoxia-inducible factor HIF ihhibitor (FIH1)
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 1mze, assembly 1, front view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 1mze, assembly 1, side view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 1mze, assembly 1, top view.
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