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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE DIPHOSPHATE (TDP) AND THYMIDINE TRIPHOSPHATE (TTP) AT PH 5.4 (1.85 A RESOLUTION)

X-ray diffraction
1.85Å resolution
PDB entry 1n5j coloured by chain, front view.
PDB entry 1n5j coloured by chain, side view.
PDB entry 1n5j coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Thymidylate kinase
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Multimeric state: homo dimer
Accessible surface area: 16465.99 Å2
Buried surface area: 5798.11 Å2
Dissociation area: 819.96 Å2
Dissociation energy (ΔGdiss): 4.84 kcal/mol
Dissociation entropy (TΔSdiss): 12.43 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161736

Macromolecules

Thymidylate kinase
Chain: A
Length: 214 amino acids
Theoretical weight: 22.66 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKE1 (Residues: 1-214; Coverage: 100%)
Gene names: Rv3247c, tmk
Pfam: Thymidylate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: Nucleotide and nucleoside kinases
Thymidylate kinase in PDB entry 1n5j, assembly 1, front view.
Thymidylate kinase in PDB entry 1n5j, assembly 1, side view.
Thymidylate kinase in PDB entry 1n5j, assembly 1, top view.
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