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CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR132747

X-ray diffraction
2.05Å resolution
PDB entry 1nfu coloured by chain, front view.
PDB entry 1nfu coloured by chain, side view.
PDB entry 1nfu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor Xa complex
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Multimeric state: hetero dimer
Accessible surface area: 13530.78 Å2
Buried surface area: 2503.4 Å2
Dissociation area: 808.46 Å2
Dissociation energy (ΔGdiss): 5.35 kcal/mol
Dissociation entropy (TΔSdiss): 10.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133209
Complex Portal ID: CPX-6215

Macromolecules

Activated factor Xa heavy chain
Chain: A
Length: 254 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-488; Coverage: 56%)
Gene name: F10
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Activated factor Xa heavy chain in PDB entry 1nfu, assembly 1, front view.
Activated factor Xa heavy chain in PDB entry 1nfu, assembly 1, side view.
Activated factor Xa heavy chain in PDB entry 1nfu, assembly 1, top view.
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Activated factor Xa heavy chain
Chain: B
Length: 195 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 46-240; Coverage: 43%)
Gene name: F10
Pfam:
InterPro:
CATH: Laminin
SCOP: EGF-type module
Activated factor Xa heavy chain in PDB entry 1nfu, assembly 1, front view.
Activated factor Xa heavy chain in PDB entry 1nfu, assembly 1, side view.
Activated factor Xa heavy chain in PDB entry 1nfu, assembly 1, top view.
Molecule details ›

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