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HUMAN PYRUVATE DEHYDROGENASE

X-ray diffraction
1.95Å resolution
PDB entry 1ni4 coloured by chain, front view.
PDB entry 1ni4 coloured by chain, side view.
PDB entry 1ni4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pyruvate dehydrogenase E1 heterotetramer
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Multimeric state: hetero tetramer
Accessible surface area: 42348.25 Å2
Buried surface area: 22244.77 Å2
Dissociation area: 6,294.77 Å2
Dissociation energy (ΔGdiss): 102.3 kcal/mol
Dissociation entropy (TΔSdiss): 16.76 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-140174
Complex Portal ID: CPX-376

Macromolecules

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Chains: A, C
Length: 365 amino acids
Theoretical weight: 41.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08559 (Residues: 30-390; Coverage: 93%)
Gene names: PDHA1, PHE1A
Pfam: Dehydrogenase E1 component
InterPro:
CATH: Rossmann fold
SCOP: Branched-chain alpha-keto acid dehydrogenase PP module
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial in PDB entry 1ni4, assembly 1, front view.
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial in PDB entry 1ni4, assembly 1, side view.
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial in PDB entry 1ni4, assembly 1, top view.
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Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Chains: B, D
Length: 341 amino acids
Theoretical weight: 37.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11177 (Residues: 31-359; Coverage: 92%)
Gene names: PDHB, PHE1B
Pfam:
InterPro:
CATH:
SCOP:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial in PDB entry 1ni4, assembly 1, front view.
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial in PDB entry 1ni4, assembly 1, side view.
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial in PDB entry 1ni4, assembly 1, top view.
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