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Crystal structure of the CUB1-EGF-CUB2 region of MASP2

Source organism: Rattus norvegicus
Biochemical function: calcium ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.4.21.104: Mannan-binding lectin-associated serine protease-2

Reaction catalysed:
Selective cleavage after Arg(223) in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg(76) in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile)
Systematic name:
-
Alternative Name(s):
  • MASP-2
  • MASP2
  • MBP-associated serine protease-2
  • Mannan-binding lectin-associated serine peptidase 2
  • Mannose-binding lectin-associated serine protease-2
  • P100

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00431
Domain description: CUB domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
The deposited structure of PDB entry 1nt0 contains 4 copies of Pfam domain PF00431 (CUB domain) in Mannan-binding lectin serine protease 2 A chain. Showing 2 copies in chain A.

PF07645
Domain description: Calcium-binding EGF domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
The deposited structure of PDB entry 1nt0 contains 2 copies of Pfam domain PF07645 (Calcium-binding EGF domain) in Mannan-binding lectin serine protease 2 A chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000859
Domain description: CUB domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
IPR035914
Domain description: Spermadhesin, CUB domain superfamily
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
IPR018097
Domain description: EGF-like calcium-binding, conserved site
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain

Structure domains

CATH CATH domains
2.60.120.290
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Spermadhesin, CUB domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
The deposited structure of PDB entry 1nt0 contains 4 copies of CATH domain 2.60.120.290 (Jelly Rolls) in Mannan-binding lectin serine protease 2 A chain. Showing 2 copies in chain A.
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
The deposited structure of PDB entry 1nt0 contains 2 copies of CATH domain 2.10.25.10 (Laminin) in Mannan-binding lectin serine protease 2 A chain. Showing 1 copy in chain A.
SCOP SCOP annotations
49855
Class: All beta proteins
Fold: CUB-like
Superfamily: Spermadhesin, CUB domain
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
The deposited structure of PDB entry 1nt0 contains 4 copies of SCOP domain 49855 (Spermadhesin, CUB domain) in Mannan-binding lectin serine protease 2 A chain. Showing 2 copies in chain A.
57197
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Mannan-binding lectin serine protease 2 A chain
The deposited structure of PDB entry 1nt0 contains 2 copies of SCOP domain 57197 (EGF-type module) in Mannan-binding lectin serine protease 2 A chain. Showing 1 copy in chain A.

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