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Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(H) and Mg2+

X-ray diffraction
2.15Å resolution
PDB entry 1o01 coloured by chain, front view.
PDB entry 1o01 coloured by chain, side view.
PDB entry 1o01 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aldehyde dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 56531.87 Å2
Buried surface area: 29642.73 Å2
Dissociation area: 5,354.51 Å2
Dissociation energy (ΔGdiss): 23.99 kcal/mol
Dissociation entropy (TΔSdiss): 16.82 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-138420
Assembly 2
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Assembly Name: Aldehyde dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 56364.32 Å2
Buried surface area: 29614.4 Å2
Dissociation area: 5,262.86 Å2
Dissociation energy (ΔGdiss): 24.71 kcal/mol
Dissociation entropy (TΔSdiss): 16.8 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-138420

Macromolecules

Aldehyde dehydrogenase, mitochondrial
Chains: A, B, C, D, E, F, G, H
Length: 500 amino acids
Theoretical weight: 54.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P05091 (Residues: 18-517; Coverage: 97%)
Gene names: ALDH2, ALDM
Pfam: Aldehyde dehydrogenase family
InterPro:
CATH:
SCOP: ALDH-like
Aldehyde dehydrogenase, mitochondrial in PDB entry 1o01, assembly 1, front view.
Aldehyde dehydrogenase, mitochondrial in PDB entry 1o01, assembly 1, side view.
Aldehyde dehydrogenase, mitochondrial in PDB entry 1o01, assembly 1, top view.
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