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TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00505
Domain description: HMG (high mobility group) box
Occurring in:
  1. Transcription factor SOX-2
The deposited structure of PDB entry 1o4x contains 1 copy of Pfam domain PF00505 (HMG (high mobility group) box) in Transcription factor SOX-2. Showing 1 copy in chain D [auth B].

PF00046
Domain description: Homeodomain
Occurring in:
  1. POU domain, class 2, transcription factor 1
The deposited structure of PDB entry 1o4x contains 1 copy of Pfam domain PF00046 (Homeodomain) in POU domain, class 2, transcription factor 1. Showing 1 copy in chain C [auth A].

PF00157
Domain description: Pou domain - N-terminal to homeobox domain
Occurring in:
  1. POU domain, class 2, transcription factor 1
The deposited structure of PDB entry 1o4x contains 1 copy of Pfam domain PF00157 (Pou domain - N-terminal to homeobox domain) in POU domain, class 2, transcription factor 1. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR013847
Domain description: POU domain
Occurring in:
  1. POU domain, class 2, transcription factor 1
IPR000327
Domain description: POU-specific domain
Occurring in:
  1. POU domain, class 2, transcription factor 1
IPR001356
Domain description: Homeodomain
Occurring in:
  1. POU domain, class 2, transcription factor 1
IPR009071
Domain description: High mobility group box domain
Occurring in:
  1. Transcription factor SOX-2
IPR036910
Domain description: High mobility group box domain superfamily
Occurring in:
  1. Transcription factor SOX-2
IPR010982
Domain description: Lambda repressor-like, DNA-binding domain superfamily
Occurring in:
  1. POU domain, class 2, transcription factor 1
IPR017970
Domain description: Homeobox, conserved site
Occurring in:
  1. POU domain, class 2, transcription factor 1
IPR009057
Domain description: Homedomain-like superfamily
Occurring in:
  1. POU domain, class 2, transcription factor 1

Structure domains

CATH CATH domains
1.10.30.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA Binding (I), subunit A
Homology: High mobility group box domain
Occurring in:
  1. Transcription factor SOX-2
The deposited structure of PDB entry 1o4x contains 1 copy of CATH domain 1.10.30.10 (DNA Binding (I), subunit A) in Transcription factor SOX-2. Showing 1 copy in chain D [auth B].
1.10.10.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Homeodomain-like
Occurring in:
  1. POU domain, class 2, transcription factor 1
The deposited structure of PDB entry 1o4x contains 1 copy of CATH domain 1.10.10.60 (Arc Repressor Mutant, subunit A) in POU domain, class 2, transcription factor 1. Showing 1 copy in chain C [auth A].
1.10.260.40
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: 434 Repressor (Amino-terminal Domain)
Homology: lambda repressor-like DNA-binding domains
Occurring in:
  1. POU domain, class 2, transcription factor 1
The deposited structure of PDB entry 1o4x contains 1 copy of CATH domain 1.10.260.40 (434 Repressor (Amino-terminal Domain)) in POU domain, class 2, transcription factor 1. Showing 1 copy in chain C [auth A].
SCOP SCOP annotations
47096
Class: All alpha proteins
Fold: HMG-box
Superfamily: HMG-box
Occurring in:
  1. Transcription factor SOX-2
The deposited structure of PDB entry 1o4x contains 1 copy of SCOP domain 47096 (HMG-box) in Transcription factor SOX-2. Showing 1 copy in chain D [auth B].
46690
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: Homeodomain-like
Occurring in:
  1. POU domain, class 2, transcription factor 1
The deposited structure of PDB entry 1o4x contains 1 copy of SCOP domain 46690 (Homeodomain) in POU domain, class 2, transcription factor 1. Showing 1 copy in chain C [auth A].
47414
Class: All alpha proteins
Fold: lambda repressor-like DNA-binding domains
Superfamily: lambda repressor-like DNA-binding domains
Occurring in:
  1. POU domain, class 2, transcription factor 1
The deposited structure of PDB entry 1o4x contains 1 copy of SCOP domain 47414 (POU-specific domain) in POU domain, class 2, transcription factor 1. Showing 1 copy in chain C [auth A].

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