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TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT

Solution NMR
PDB entry 1o4x coloured by chain, front view.
PDB entry 1o4x coloured by chain, side view.
PDB entry 1o4x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: POU domain, class 2, transcription factor 1 and Transcription factor SOX-2 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 17918.79 Å2
Buried surface area: 7117.71 Å2
Dissociation area: 1,642.38 Å2
Dissociation energy (ΔGdiss): -1.06 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114296

Macromolecules

POU domain, class 2, transcription factor 1
Chain: A
Length: 167 amino acids
Theoretical weight: 19.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14859 (Residues: 280-442; Coverage: 22%)
Gene names: OCT1, OTF1, POU2F1
Pfam:
InterPro:
CATH:
SCOP:
POU domain, class 2, transcription factor 1 in PDB entry 1o4x, assembly 1, front view.
POU domain, class 2, transcription factor 1 in PDB entry 1o4x, assembly 1, side view.
POU domain, class 2, transcription factor 1 in PDB entry 1o4x, assembly 1, top view.
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Transcription factor SOX-2
Chain: B
Length: 88 amino acids
Theoretical weight: 10.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48431 (Residues: 39-121; Coverage: 26%)
Gene name: SOX2
Pfam: HMG (high mobility group) box
InterPro:
CATH: High mobility group box domain
SCOP: HMG-box
Transcription factor SOX-2 in PDB entry 1o4x, assembly 1, front view.
Transcription factor SOX-2 in PDB entry 1o4x, assembly 1, side view.
Transcription factor SOX-2 in PDB entry 1o4x, assembly 1, top view.
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DNA chain C
Name: 5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3'
Representative chains: C
Length: 19 nucleotides
Theoretical weight: 5.82 KDa
5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3' in PDB entry 1o4x, assembly 1, front view.
5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3' in PDB entry 1o4x, assembly 1, side view.
5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3' in PDB entry 1o4x, assembly 1, top view.
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DNA chain D
Name: 5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3'
Representative chains: D
Length: 19 nucleotides
Theoretical weight: 5.83 KDa
5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3' in PDB entry 1o4x, assembly 1, front view.
5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3' in PDB entry 1o4x, assembly 1, side view.
5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3' in PDB entry 1o4x, assembly 1, top view.
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